What is Spermidine?
A 2018 cohort study measured spermidine from food in 829 adults aged 45 to 84. Supplement studies have measured levels in blood and saliva instead.
Why it comes up for skin and aging
We found no human skin trial of spermidine in the sources reviewed, so no skin benefit is shown.
What the research shows
In the 2018 cohort, followed for about 20 years with 341 deaths, the fully adjusted hazard ratio was 0.76 per standard deviation of higher spermidine intake (95% CI 0.67 to 0.86). The study is observational, so it does not prove cause.
A randomized, placebo-controlled trial in healthy adults found that high-dose spermidine supplementation did not raise spermidine levels in blood plasma or saliva.
Forms, amounts and limits
The sources reviewed do not establish a supplement dose for any health outcome. The cohort measured dietary intake.
Safety
We did not verify human safety data for spermidine supplements in the sources reviewed. Ask a clinician before use if you take medicines or have a health condition.
Talk to a doctor or pharmacist before starting any supplement, especially if you are pregnant, breastfeeding, have a medical condition or take medicines.
Questions
Is spermidine proven to extend life?
No. The lifespan link comes from an observational study of diet. We found no supplement trial of lifespan in the sources reviewed.
Sources
- Kiechl et al. 2018: Higher spermidine intake is linked to lower mortality (PubMed 29955838) (opens in a new tab)
- High-dose spermidine supplementation and plasma and saliva levels in healthy adults (PMC10143675) (opens in a new tab)
General information, not medical advice. Vanu Health does not sell this supplement. Read our terms.