What is Fisetin?
Fisetin is studied as a senolytic, a compound that may clear senescent (aged) cells. The 2018 study tested this in mice and in human fat-tissue explants.
Why it comes up for skin and aging
We found no human skin outcome from fisetin in the sources reviewed.
What the research shows
In the 2018 study, mice given fisetin later in life had longer median and maximal lifespan. Group sizes were 8 to 9 mice, and the exact numbers appear only in the figures.
The human part used fat-tissue explants from three women aged 55 to 66. It was not a clinical outcome study.
The 2018 authors disclosed financial interests, and the Mayo Clinic holds senolytic patents.
Forms, amounts and limits
The mouse study used fisetin in feed at 500 ppm (about 60 mg/kg a day) and gavage doses of 100 mg/kg for 5 days. These are animal doses, and the sources reviewed do not set a human dose.
Safety
In the 2024 UV mouse study, oral fisetin in feed at 100 mg/kg a day affected the timing of the third tumour (p = 0.021). Tumour growth was not significant (p = 0.129).
The authors conclude that quercetin and fisetin may have co-carcinogenic properties under UV exposure, and they advise caution when choosing photoprotectant candidates.
Long-term safety in people is not reported in the sources reviewed.
Talk to a doctor or pharmacist before starting any supplement, especially if you are pregnant, breastfeeding, have a medical condition or take medicines.
Questions
Is fisetin a senolytic drug?
Fisetin is studied as a senolytic. The key 2018 study reported no human clinical outcomes, and its lifespan result is from mice.
Does fisetin extend life in people?
Not shown. The lifespan result comes from mice.
Sources
- Yousefzadeh et al. 2018, EBioMedicine: fisetin senolytic study (PMC6197652) (opens in a new tab)
- Pihl et al. 2024: oral quercetin and fisetin in UV-exposed hairless mice (opens in a new tab)
General information, not medical advice. Vanu Health does not sell this supplement. Read our terms.