| Duteil, 2014Single wavelengths on volunteers. | Healthy volunteers with skin types III and IV, irradiated with 415 nm and 630 nm light and with UVB, with colour, clinical and histological assessment.2 | 415 nm showed a clear dose effect. 630 nm did not darken skin. Blue-violet light caused more pronounced hyperpigmentation than UVB, lasting up to 3 months.2 | A single narrow wavelength at controlled doses, not a screen. UVB caused more keratinocyte necrosis and p53 than either light.2 |
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| Regazzetti, 2017Mechanism. | Laboratory work on melanocytes and skin samples.1 | Opsin-3 acts as the sensor for visible-light pigmentation, through a calcium-dependent pathway that raises tyrosinase.1 | Explains how, not how much from daily life. One author is from L’Oréal Research and Innovation.1 |
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| Liebel, 2012Visible light, 400 to 700 nm. | Human skin equivalents, plus clinical models of free radical activity.3 | Visible light induced reactive oxygen species, inflammatory cytokines and MMP-1. Commercially available sunscreens had minimal effect on the oxidative response.3 | Whole visible spectrum, not blue alone. The lead author is at a Johnson & Johnson skin research centre, and the sunscreen tested contained an antioxidant combination.3 |
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| Li, 2023Blue light in melasma. | Observational, 42 women (21 with melasma, 21 healthy), skin types III and IV, blue light on unexposed skin.8 | Pigmentation appeared in both groups. At 20 J/cm² the change was smaller in melasma patients. At 40 to 80 J/cm² the effect was similar.8 | Small, observational, and measured on non-exposed skin.8 |
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| Duteil, 2020Letter, JAAD. | Randomized controlled trial, published as a letter, of short-term device blue light in melasma.5 | Its title states that short-term exposure to blue light emitted by electronic devices does not worsen melasma.5 | PubMed carries no abstract for this letter, so we report only its title and study type. |
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| Ceresnie, 2022Systematic review. | Of 88 records found, 9 met the criteria (6 in vitro, 3 in vivo), graded with an OHAT hazard framework.6 | Did not identify device blue light as a hazard to pigmentation, redness, yellowness or melasma exacerbation, and did not classify it as a photoaging hazard.6 | Low confidence in exposure characterization drove high risk-of-bias ratings. The authors call for more high-confidence studies.6 |
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| de Gálvez, 2022Dose comparison. | Compared effective irradiance from the sun, indoor lighting and electronic devices using reference equations.7 | The sun was the main source of effective irradiance for pigmentation and oxidative stress. Device exposure was significantly lower.7 | The authors say device exposure still adds up as a cumulative dose, especially in people with hypersensitivity.7 |
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| Arjmandi, 2018Narrative review. | Reviews device light and smartphone flash effects on skin cells.14 | Reports that exposure of skin cells to device light, even for 1 hour, may cause reactive oxygen species, apoptosis and necrosis.14 | Cell-level findings. It says the effects of long-term or repeated exposure are not fully known.14 |
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